Despite the title and lyrics, the intent was humorous and non-serious, and La Beouf appeared at the end of the video, applauding.

The same year he provided the voice of Asbel in the Disney-produced English dub of Nausicaä of the Valley of the Wind.

La Beouf made his directorial debut with the short film Let's Love Hate with Lorenzo Eduardo.

His next film was Eagle Eye, released on September 26.

His performance received mixed reviews, with Josh Bell of Las Vegas Weekly saying he "makes a credible bid for action-hero status, although his occasional stabs at emotional depth don't really go anywhere." In February, La Beouf made his music video directorial debut, directing the video for "I Never Knew You", a single by American rapper Cage, from his third album Depart from Me (2009).

La Beouf later appeared in its sequels Transformers: Revenge of the Fallen (2009) and Transformers: Dark of the Moon (2011), both also box office successes.

In 2008, he played Henry "Mutt Williams" Jones III in Indiana Jones and the Kingdom of the Crystal Skull, the fourth film in the Indiana Jones franchise.His other films include Wall Street: Money Never Sleeps (2010), Lawless (2012), The Company You Keep (2012), Nymphomaniac (2013) and Fury (2014).Since 2014, La Beouf has pursued a variety of public performance art projects with La Beouf, Rönkkö & Turner.In 2015, La Beouf appeared in #INTRODUCTIONS, a half-hour video made by La Beouf, Rönkkö & Turner in collaboration with Central Saint Martins Fine Art students, comprising a series of short monologues performed by La Beouf in front of a green screen.dubbed "Just Do It" after the Nike slogan, became an Internet meme after going viral within days of being released, spawning numerous remixes and parodies, and becoming the most searched for GIF of 2015 according to Google.In Indiana Jones and the Kingdom of the Crystal Skull (2008) he was Indiana Jones' greaser son Mutt Williams.